Le nostre principali pubblicazioni

2021

Storage of Mutant Human SOD1 in Non-Neural Cells from the Type-1 Amyotrophic Lateral Sclerosis ratG93A Model Correlated with the Lysosomes’ Dysfunction.

Bicchi I, Morena F, Argentati C, Nodari LR, Emiliani C, Gelati M, Vescovi AL, Martino S.
Biomedicines, August 2021

Generation of an induced pluripotent stem cell line (CSS012-A (7672)) carrying the p.G376D heterozygous mutation in the TARDBP protein.

D’Anzi A, Altieri F, Perciballi E, Ferrari D, Torres B, Bernardini L, Lattante S, Sabatelli M, Vescovi AL, Rosati J.
Stem Cell Research 2021 May;

Culturing and Expansion of “Clinical Grade” Neural Stem Cells from the Fetal Human Central Nervous System.

Gelati M, Profico DC, Ferrari D, Vescovi AL.
Methods Mol Biol. 2022

2020

Generation of an induced pluripotent stem cell line, CSSi011-A (6534), from an Amyotrophic lateral sclerosis patient with heterozygous L145F mutation in SOD1 gene

D’Anzi A, Altieri F, Perciballi E, Ferrari D, Bernardini L, Goldoni M, Mazzini L, De Marchi F, Di Pierro A, D’Alfonso S, Gelati M,Vescovi AL, Rosati J.
Stem Cell Research – July 2020

2019

Multifunctionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries

Marchini A, Raspa A, Pugliese R, El Malek MA, Pastori V, Lecchi M,Vescovi AL, Gelain F.
PNAS – March 2019 

Transplantation of clinical-grade human neural stem cells reduces neuroinflammation, prolongs survival and delays disease progression in the SOD1 rats

Zalfa C, Rota Nodari L, Vacchi E, Gelati M, Profico D, Boido M, Binda E, De Filippis L, Copetti M, Garlatti V, Daniele P, Rosati J, De Luca A, Pinos F, Cajola L, Visioli A, Mazzini L, Vercelli A, Svelto M,Vescovi AL, Ferrari D.
Cell Death & Disease – April 2019

Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome

Mazzini L, Gelati M, Profico DC, Sorarù G, Ferrari D, Copetti M, Muzi G, Ricciolini C, Carletti S, Giorgi C, Spera C, Frondizi D, Masiero S, Stecco A, Cisari C, Bersano E, De Marchi F, Sarnelli MF, Querin G, Cantello R, Petruzzelli F, Maglione A, Zalfa C, Binda E, Visioli A, Trombetta D, Torres B, Bernardini L, Gaiani A, Massara M, Paolucci S, Boulis NM,Vescovi AL; ALS-NSCs Trial Study Group.
Stem Cells Translational Medicine – May 2019

Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism

Pacelli C, Rotundo G, Lecce L, Menga M, Bidollari E, Scrima R, Cela O, Piccoli C, Cocco T,Vescovi AL, Mazzoccoli G, Rosati J, Capitanio N.
International Journal Of Molecular Sciences – June 2019

Production and characterization of human induced pluripotent stem cells (iPSC) CSSi007-A (4383) from Joubert Syndrome

Altieri F, D’Anzi A, Martello F, Tardivo S, Spasari I, Ferrari D, Bernardini L, Lamorte G, Mazzoccoli G, Valente EM,Vescovi AL, Rosati J.
Stem Cell Research – June 2019

Generation of induced pluripotent stem cell line CSSi008-A (4698) from a patient affected by advanced stage of Dentato-Rubral-Pallidoluysian atrophy (DRPLA)

Bidollari E, Rotundo G, Altieri F, Amicucci M, Wiquel D, Ferrari D, Goldoni M, Bernardini L,Consoli F, De Luca A, Fanelli S, Lamorte G, D’Agruma L,Vescovi AL, Squitieri F, Rosati J.
Stem Cell Research – August 2019

2018

Generation of induced pluripotent stem cell line, CSSi002-A (2851), from a patient with juvenile Huntington Disease.

Rosati J, Bidollari E, Rotundo G, Ferrari D, Torres B, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Squitieri F, Vescovi AL
Stem Cell Research – January 2018

Branched peptides integrate into self-assembled nanostructures and enhance biomechanics of peptidic hydrogels

Pugliese R, Fontana F, Marchini A, Gelain F.
Acta Biomaterialia – January 2018

Toll-like receptor 4 modulation influences human neural stem cell proliferation and differentiation

Grasselli C, Ferrari D, Zalfa C, Soncini M, Mazzoccoli G, Facchini FA, Marongiu L, Granucci F, Copetti M, Vescovi AL, Peri F, De Filippis L.
Cell Death & Disease – February 2018

Production and characterization of human induced pluripotent stem cells (iPSCs) from Joubert Syndrome: CSSi001-A (2850).

Rosati J, Altieri F, Tardivo S, Turco EM, Goldoni M, Spasari I, Ferrari D, Bernardini L, Lamorte G, Valente EM, Vescovi AL.
Stem Cell Research – March 2018

Generation of the induced pluripotent stem cell line CSSi006-A (3681) from a patient affected by advanced-stage Juvenile Onset Huntington’s Disease

Rotundo G, Bidollari E, Ferrari D, Spasari I, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Migliore S, Squitieri F, Vescovi AL, Rosati J
Stem Cell Research – April 2018

Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington’s disease at the presymptomatic stage

Bidollari E, Rotundo G, Ferrari D, Candido O, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Ilari A, Squitieri F, Vescovi AL, Rosati J.
Stem Cell Research – April 2018

Production and characterization of CSSI003 (2961) human induced pluripotent stem cells (iPSCs) carrying a novel puntiform mutation in RAI1 gene, Causative of Smith–Magenis syndrome

Altieri F, Turco EM, Vinci E, Torres B, Ferrari D, De Jaco A, Mazzoccoli G, Lamorte G, Nardone A, Della Monica M, Bernardini L, Vescovi AL, Rosati J.
Stem Cell Research – April 2018

Feasible stabilization of chondroitinase abc enables reduced astrogliosis in a chronic model of spinal cord injury Raspa A, Bolla E, Cuscona C, Gelain F

CNS Neuroscience & Therapeutics – May 2018

Elucidating self-assembling peptide aggregation via Morphoscanner: a new tool for protein-protein structural characterization

Saracino GAA, Fontana F, Jekhmane S, Silva JM, Weingarth M, Gelain F
Advanced Science – June 2018

Advances in stem cell therapy for amyotrophic lateral sclerosis

Mazzini L, Ferrari D, Andjus PR, Buzanska L, Cantello R, De Marchi F, Gelati M, Giniatullin R, Glover JC, Grilli M, Kozlova EN, Maioli M, Mitrečić D, Pivoriunas A, Sanchez-Pernaute R, Sarnowska A, Vescovi AL
Expert Opinion On Biological Therapy – August 2018

Establishment of stable iPS-derived human neural stem cell lines suitable for cell therapies

Rosati J, Ferrari D, Altieri F, Tardivo S, Ricciolini C, Fusilli C, Zalfa C, Profico DC, Pinos F, Bernardini L, Torres B, Manni I, Piaggio G, Binda E, Copetti M, Lamorte G, Mazza T, Carella M, Gelati M, Valente EM, Simeone A,Vescovi
Cell Death & Disease – September 2018

Human Fetal Neural Stem Cells for Neurodegenerative Disease Treatment.

Ferrari D, Gelati M, Profico DC, Vescovi AL
Results And Problems In Cell Differentiation – 2018

2017

Fabrication of nanofibrous electrospun scaffolds from a heterogeneous library of co- and self-assembling peptides”

A cura di Mahboubeh Maleki, Antonino Natalello, Raffaele Pugliese, Fabrizio Gelain
Acta Biomaterialia – January 2017

Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques.

Napolitano F, Booth Warren E, Migliarini S, Punzo D, Errico F, Li Q, Thiolat ML, Vescovi AL, Calabresi P, Bezard E, Morelli M, Konradi C, Pasqualetti M, Usiello A.
PLOS ONE – July 2017

Extracellular vesicles are independent metabolic units with asparaginase activity

Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S.
Nature Chemical Biology – September 2017

2016

Stem cells therapy for ALS

Mazzini L, Vescovi A, Cantello R, Gelati M, Vercelli A.
Expert Opinion On Biological Therapy – January 2016

A biocompatibility study of new nanofibrous scaffolds for nervous system regeneration.

Raspa A., Marchini A., Pugliese R., Mauri M., Maleki M., Vasita R., Gelain F.
Nanoscale – January 2016

Recent therapeutic approaches for spinal cord injury

Raspa A, Pugliese R, Maleki M, Gelain F.
Biotechnology & Bioengineering – February 2016

Glial degeneration with oxidative damage drives neuronal demise in MPSII disease

Cristina Zalfa, Chiara Verpelli, Francesca D’Avanzo, Rosella Tomanin, Cinzia Vicidomini, Laura Cajola, Renzo Manara, Carlo Sala, Maurizio Scarpa, Angelo Luigi Vescovi, Lidia De Filippis
Cell Death & Disease – August 2016

Peptidic biomaterials: from self-assembling to regenerative medicine

Pugliese R. and Gelain F.
Trends in Biotechnology – October 2016

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

A cura di: Atassi N., Beghi E., Blanquer M., Boulis NM., Cantello R., Caponnetto C., Chiò A., Dunnett SB., Feldman EL., Vescovi A., Mazzini L. – Collaboratori: Bendotti C., Bersano E., Brajkovic S., Car P., De Marchi F., Fantozzi R., Follenzi A., Gelati M., Giorgi C., Grilli M., Guenzi P., La Bella V., Mancardi GL., Panzarasa G., Poloni M., Profico D., Silani V., Sorarù G., Spataro R., Stecco A., Vercelli A.
Cytotherapy – Ottobre 2016

2015

Human neural stem cell transplantation in ALS: initial results from a phase I trial.

Mazzini L, Gelati M, Profico DC, Sgaravizzi G, Projetti Pensi M, Muzi G, Ricciolini C, Rota Nodari L, Carletti S, Giorgi C, Spera C, Domenico F, Bersano E, Petruzzelli F, Cisari C, Maglione A, Sarnelli MF, Stecco A, Querin G, Masiero S, Cantello R, Ferrari D, Zalfa C, Binda E, Visioli A, Trombetta D, Novelli A, Torres B, Bernardini L, Carriero A, Prandi P, Servo S, Cerino A, Cima V, Gaiani A, Nasuelli N, Massara M, Glass J, Sorarù G, Boulis NM, Vescovi AL.
Journal Of Translational Medicine – January 2015

The Big Bluff of Amyotrophic Lateral Sclerosis Diagnosis: The Role of Neurodegenerative Disease Mimics.

Bicchi I, Emiliani C, Vescovi A, Martino S.
Neurodegenerative Diseases – 2015

2014

Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury.

Cigognini D, Silva D, Paloppi S, Gelain F
Journal of Biomedical Nanotechnology – February 2014

Modeling and analysis of early aggregation events of BMHP1-derived self-assembling peptides

Saracino G and Gelain F
Journal of Biomolecular Structure & Dynamics – 2014

Adult stem cell as new advanced therapy for experimental neuropathic pain treatment.

Franchi S, Castelli M, Amodeo G, Niada S, Ferrari D, Vescovi A, Brini AT, Panerai AE, Sacerdote P.
Biomed Research International – 2014

2013

Synthesis and Characterization of Designed BMHP1-Derived Self-Assembling Peptides for tissue engineering applications

Silva D, Natalello A, Sanii B, Vasita R, Saracino GAA, Zuckermann RN, Doglia SM, Gelain F
Nanoscale – January 2013

A Novel Bioactive Peptide: Assessing its Activity Over Murine Neural Stem Cells and its Potential for Neural Tissue Engineering

Caprini A, Silva D, Zanoni I, Cunha C, Volontè C, Vescovi A, Gelain F
New Biotechnology – June 2013

Murine neural stem cells model Hunter disease in vitro: glial cell-mediated neurodegeneration as a possible mechanism involved

Fusar Poli E, Zalfa C, D’Avanzo F, Tomanin R, Carlessi L, Bossi M, Nodari LR, Binda E, Marmiroli P, Scarpa M, Delia D, Vescovi AL, De Filippis L.
Cell Death & Disease – November 2013

Culturing and expansion of “clinical grade” precursors cells from the fetal human central nervous system.

Gelati M, Profico D, Projetti-Pensi M, Muzi G, Sgaravizzi G, Vescovi AL.
Methods In Molecular Biology – 2013

2012

Differential pathotropism of non-immortalized and immortalized human neural stem cell lines in a focal demyelination model.

Ferrari D, Zalfa C, Nodari LR, Gelati M, Carlessi L, Delia D, Vescovi AL, De Filippis L.
Cellular And Molecular Life Sciences – April 2012

Long-term survival of human neural stem cells in the ischemic rat brain upon transient immunosuppression.

Franchi S, Valsecchi AE, Borsani E, Procacci P, Ferrari D, Zalfa C, Sartori P, Rodella LF, Vescovi A, Maione S, Rossi F, Sacerdote P, Colleoni M, Panerai AE.
Pain – April 2012

New Bioactive Motifs and Their Use in Functionalized Self-Assembling Peptides for NSC Differentiation and Neural Tissue Engineering

Gelain F, Cigognini D, Caprini A, Silva D, Colleoni B, Donegá B, Antonini S, Cohen BE, Vescovi A.
Nanoscale – April 2012

Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration in experimental neuropathy.

Franchi S, Valsecchi AE, Borsani E, Procacci P, Ferrari D, Zalfa C, Sartori P, Rodella LF, Vescovi A, Maione S, Rossi F, Sacerdote P, Colleoni M, Panerai AE.
Pain – April 2012

Nanomaterials design and tests for neural tissue engineering

Saracino GAA, Cigognini D, Silva D, Caprini A, Gelain F
Chemical Society Reviews – September 2012

2011

Transplantation of nanostructured composite scaffolds neuro-prosthetics results in tissue reconstruction, axonal regeneration and neurological recovery in the chronically injured rat spinal cord

Gelain F, Panseri S, Antonini S, Cunha C, Donega M, Lowery J, Taraballi F, Cerri G, Montagna M, Baldissera F, Vescovi A.
ACS Nano – January 2011

BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications

Gelain F, Silva D, Caprini A, Villa O, Taraballi F, Natalello A, Nam KT, Doglia SM, Vescovi A.
ACS Nano – March 2011

Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-assembling Scaffold

Cigognini D, Satta A, Colleoni B, Silva D, Donega’ M, Antonini S, Gelain F
PLOS ONE – May 2011

2010

GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex.

Middeldorp J, Boer K, Sluijs JA, De Filippis L, Encha-Razavi F, Vescovi AL, Swaab DF, Aronica E, Hol EM.
Development. – January 2010

Mild hypoxia enhances proliferation and multipotency of human neural stem cells.

Santilli G, Lamorte G, Carlessi L, Ferrari D, Rota Nodari L, Binda E, Delia D, Vescovi AL, De Filippis L.
PLOS ONE – January 2010

Robust generation of oligodendrocyte progenitors from human neural stem cells and engraftment in experimental demyelination models in mice.

Neri M, Maderna C, Ferrari D, Cavazzin C, Vescovi AL, Gritti A.
PLOS ONE – April 2010

Isolation of neural stem cells from neural tissues using the neurosphere technique.

Ferrari D, Binda E, De Filippis L, Vescovi AL.
Current Protocols In Stem Cell Biology – November 2010

Long-term survival of human neural stem cells in the ischemic rat brain upon transient immunosuppression

Rota Nodari L, Ferrari D, Giani F, Bossi M, Rodriguez-Menendez V, Tredici G, Delia D, Vescovi AL, De Filippis L.
Current Protocols In Stem Cell Biology – November 2010

2009

The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions.

Regenberg A, Mathews DJ, Blass DM, Bok H, Coyle JT, Duggan P, Faden R, Finkel J, Gearhart JD, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, King P, Kurtzberg J, Liao SM, McDonald JW, McKhann G, Nelson KB, Rao M, Siegel AW, Smith K, Solter D, Song H, Sugarman J, Vescovi A, Young W, Greely HT, Traystman RJ.
Journal Of Cerebral Blood Flow & Metabolism – January 2009

Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates.

Pluchino S, Gritti A, Blezer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, ‘t Hart B, Vescovi A, Martino G.
Annals Of Neurology – September 2009

2008

Efficient in vitro labeling of human neural precursor cells with superparamagnetic iron oxide particles: relevance for in vivo cell tracking

Neri M, Maderna C, Cavazzin C, Deidda-Vigoriti V, Politi LS, Scotti G, Marzola P, Sbarbati A, Vescovi AL, Gritti A.
Stem Cells Research – February 2008

Adult neural stem cells.

Galli R, Gritti A, Vescovi AL.
Methods In Molecular Biology – 2008

Clonal analyses and cryopreservation of neural stem cell cultures.

Gritti A, Galli R, Vescovi AL.
Methods In Molecular Biology – 2008

Multipotential neural precursors transplanted into the metachromatic leukodystrophy brain fail to generate oligodendrocytes but contribute to limit brain dysfunction.

Givogri MI, Bottai D, Zhu HL, Fasano S, Lamorte G, Brambilla R, Vescovi A, Wrabetz L, Bongarzone E.
Developmental Neuroscience – 2008

2007

Learning in human neural networks on microelectrode arrays

Pizzi R, Cino G, Gelain F, Rossetti D, Vescovi A.L.
Methods In Molecular Biology – March 2007

The stem cells as a potential treatment for neurodegeneration.

Daniela F, Vescovi AL, Bottai D.
Methods In Molecular Biology – 2007 

A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes

De Filippis L, Lamorte G, Snyder EY, Malgaroli A, Vescovi AL.
Stem Cells – 2007

2006

Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures.

Gelain F, Bottai D, Vescovi A, Zhang S.
Journal Of Clinical Virology – December 2006

Differentiated human neural stem cells: a new ex vivo model to study HHV-6 infection of the central nervous system.

De Filippis L, Foglieni C, Silva S, Vescovi AL, Lusso P, Malnati MS. J Clin Virol.
Journal Of Clinical Virology – December 2006

2003

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis.

Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A, Furlan R, Comi G, Vescovi AL, Martino G.
Nature. – April 2003

Neural stem cells: an overview.

Galli R, Gritti A, Bonfanti L, Vescovi AL.
Circulation Research – April 2003

2002

Adult neural stem cells: plasticity and developmental potential.

Gritti A, Vescovi AL, Galli R.
Journal Of Physiology-Paris – January/March 2002

Hematopoietic potential of neural stem cells

Vescovi AL, Rietze R, Magli MC, Bjornson C.
Nature Medicine – June 2002

Clonal analyses and cryopreservation of neural stem cell cultures.

Vescovi AL, Galli R, Gritti A.
Methods In Molecular Biology – 2002

2001

The neural stem cells and their transdifferentiation capacity.

Vescovi AL, Galli R, Gritti A.
Biomedicine & Pharmacotherapy – May 2001

2000

Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS.

Villa A, Snyder EY, Vescovi A, Martínez-Serrano A.
Experimental Neurology – January 2000

The possibilities/perplexities of stem cells.

Snyder EY, Vescovi AL.
Nature Biotechnology – August 2000

Excitable properties in astrocytes derived from human embryonic CNS stem cells

Gritti A, Rosati B, Lecchi M, Vescovi AL, Wanke E.
European Journal Of Neuroscience – October 2000

Regulation of neuronal differentiation in human CNS stem cell progeny by leukemia inhibitory factor.

Galli R, Pagano SF, Gritti A, Vescovi AL.
Developmental Neuroscience – 2000

1999

Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo.

Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL.
Science. – January 1999

Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation.

Vescovi AL, Parati EA, Gritti A, Poulin P, Ferrario M, Wanke E, Frölichsthal-Schoeller P, Cova L, Arcellana-Panlilio M, Colombo A, Galli R.
Experimental Neurology – March 1999

Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain.

Gritti A, Frölichsthal-Schoeller P, Galli R, Parati EA, Cova L, Pagano SF, Bjornson CR, Vescovi AL.
Journal Of Neuroscience Research – May 1999

Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo.

Vescovi AL, Snyder EY. Brain Pathol.
Journal Of Neuroscience Research – July 1999

Isolation and intracerebral grafting of nontransformed multipotential embryonic human CNS stem cells.

Vescovi AL, Gritti A, Galli R, Parati EA.
Journal Of Neurotrama – August 1999

Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord.

Quinn SM, Walters WM, Vescovi AL, Whittemore SR.
Journal Of Neuroscience Research – September 1999

1996

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.

Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, Wanke E, Faravelli L, Morassutti DJ, Roisen F, Nickel DD, Vescovi AL.
The Journal Of Neuroscience – February 1996

Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.

Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, Wanke E, Faravelli L, Morassutti DJ, Roisen F, Nickel DD, Vescovi AL.
The Journal Of Neuroscience – February 1996


Is there a neural stem cell in the mammalian forebrain?

Weiss S, Reynolds BA, Vescovi AL, Morshead C, Craig CG, van der Kooy D.
Trends In Neuroscience – September 1996

1995

Basic fibroblast growth factor supports the proliferation of epidermal growth factor-generated neuronal precursor cells of the adult mouse CNS.

Gritti A, Cova L, Parati EA, Galli R, Vescovi AL.
Neuroscience Letters – February 1995

1993

bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells.

Vescovi AL, Reynolds BA, Fraser DD, Weiss S.
Neuron – November 1993