2021
Storage of Mutant Human SOD1 in Non-Neural Cells from the Type-1 Amyotrophic Lateral Sclerosis ratG93A Model Correlated with the Lysosomes’ Dysfunction.
Generation of an induced pluripotent stem cell line (CSS012-A (7672)) carrying the p.G376D heterozygous mutation in the TARDBP protein.
Culturing and Expansion of “Clinical Grade” Neural Stem Cells from the Fetal Human Central Nervous System.
Methods Mol Biol. 2022
2020
Generation of an induced pluripotent stem cell line, CSSi011-A (6534), from an Amyotrophic lateral sclerosis patient with heterozygous L145F mutation in SOD1 gene
D’Anzi A, Altieri F, Perciballi E, Ferrari D, Bernardini L, Goldoni M, Mazzini L, De Marchi F, Di Pierro A, D’Alfonso S, Gelati M,Vescovi AL, Rosati J.
Stem Cell Research – July 2020
2019
Multifunctionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries
Marchini A, Raspa A, Pugliese R, El Malek MA, Pastori V, Lecchi M,Vescovi AL, Gelain F.
PNAS – March 2019
Transplantation of clinical-grade human neural stem cells reduces neuroinflammation, prolongs survival and delays disease progression in the SOD1 rats
Zalfa C, Rota Nodari L, Vacchi E, Gelati M, Profico D, Boido M, Binda E, De Filippis L, Copetti M, Garlatti V, Daniele P, Rosati J, De Luca A, Pinos F, Cajola L, Visioli A, Mazzini L, Vercelli A, Svelto M,Vescovi AL, Ferrari D.
Cell Death & Disease – April 2019
Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome
Mazzini L, Gelati M, Profico DC, Sorarù G, Ferrari D, Copetti M, Muzi G, Ricciolini C, Carletti S, Giorgi C, Spera C, Frondizi D, Masiero S, Stecco A, Cisari C, Bersano E, De Marchi F, Sarnelli MF, Querin G, Cantello R, Petruzzelli F, Maglione A, Zalfa C, Binda E, Visioli A, Trombetta D, Torres B, Bernardini L, Gaiani A, Massara M, Paolucci S, Boulis NM,Vescovi AL; ALS-NSCs Trial Study Group.
Stem Cells Translational Medicine – May 2019
Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism
Pacelli C, Rotundo G, Lecce L, Menga M, Bidollari E, Scrima R, Cela O, Piccoli C, Cocco T,Vescovi AL, Mazzoccoli G, Rosati J, Capitanio N.
International Journal Of Molecular Sciences – June 2019
Production and characterization of human induced pluripotent stem cells (iPSC) CSSi007-A (4383) from Joubert Syndrome
Altieri F, D’Anzi A, Martello F, Tardivo S, Spasari I, Ferrari D, Bernardini L, Lamorte G, Mazzoccoli G, Valente EM,Vescovi AL, Rosati J.
Stem Cell Research – June 2019
Generation of induced pluripotent stem cell line CSSi008-A (4698) from a patient affected by advanced stage of Dentato-Rubral-Pallidoluysian atrophy (DRPLA)
Bidollari E, Rotundo G, Altieri F, Amicucci M, Wiquel D, Ferrari D, Goldoni M, Bernardini L,Consoli F, De Luca A, Fanelli S, Lamorte G, D’Agruma L,Vescovi AL, Squitieri F, Rosati J.
Stem Cell Research – August 2019
2018
Generation of induced pluripotent stem cell line, CSSi002-A (2851), from a patient with juvenile Huntington Disease.
Rosati J, Bidollari E, Rotundo G, Ferrari D, Torres B, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Squitieri F, Vescovi AL
Stem Cell Research – January 2018
Branched peptides integrate into self-assembled nanostructures and enhance biomechanics of peptidic hydrogels
Pugliese R, Fontana F, Marchini A, Gelain F.
Acta Biomaterialia – January 2018
Toll-like receptor 4 modulation influences human neural stem cell proliferation and differentiation
Grasselli C, Ferrari D, Zalfa C, Soncini M, Mazzoccoli G, Facchini FA, Marongiu L, Granucci F, Copetti M, Vescovi AL, Peri F, De Filippis L.
Cell Death & Disease – February 2018
Production and characterization of human induced pluripotent stem cells (iPSCs) from Joubert Syndrome: CSSi001-A (2850).
Rosati J, Altieri F, Tardivo S, Turco EM, Goldoni M, Spasari I, Ferrari D, Bernardini L, Lamorte G, Valente EM, Vescovi AL.
Stem Cell Research – March 2018
Generation of the induced pluripotent stem cell line CSSi006-A (3681) from a patient affected by advanced-stage Juvenile Onset Huntington’s Disease
Rotundo G, Bidollari E, Ferrari D, Spasari I, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Migliore S, Squitieri F, Vescovi AL, Rosati J
Stem Cell Research – April 2018
Generation of induced pluripotent stem cell line, CSSi004-A (2962), from a patient diagnosed with Huntington’s disease at the presymptomatic stage
Bidollari E, Rotundo G, Ferrari D, Candido O, Bernardini L, Consoli F, De Luca A, Santimone I, Lamorte G, Ilari A, Squitieri F, Vescovi AL, Rosati J.
Stem Cell Research – April 2018
Production and characterization of CSSI003 (2961) human induced pluripotent stem cells (iPSCs) carrying a novel puntiform mutation in RAI1 gene, Causative of Smith–Magenis syndrome
Altieri F, Turco EM, Vinci E, Torres B, Ferrari D, De Jaco A, Mazzoccoli G, Lamorte G, Nardone A, Della Monica M, Bernardini L, Vescovi AL, Rosati J.
Stem Cell Research – April 2018
Feasible stabilization of chondroitinase abc enables reduced astrogliosis in a chronic model of spinal cord injury Raspa A, Bolla E, Cuscona C, Gelain F
CNS Neuroscience & Therapeutics – May 2018
Elucidating self-assembling peptide aggregation via Morphoscanner: a new tool for protein-protein structural characterization
Saracino GAA, Fontana F, Jekhmane S, Silva JM, Weingarth M, Gelain F
Advanced Science – June 2018
Advances in stem cell therapy for amyotrophic lateral sclerosis
Mazzini L, Ferrari D, Andjus PR, Buzanska L, Cantello R, De Marchi F, Gelati M, Giniatullin R, Glover JC, Grilli M, Kozlova EN, Maioli M, Mitrečić D, Pivoriunas A, Sanchez-Pernaute R, Sarnowska A, Vescovi AL
Expert Opinion On Biological Therapy – August 2018
Establishment of stable iPS-derived human neural stem cell lines suitable for cell therapies
Rosati J, Ferrari D, Altieri F, Tardivo S, Ricciolini C, Fusilli C, Zalfa C, Profico DC, Pinos F, Bernardini L, Torres B, Manni I, Piaggio G, Binda E, Copetti M, Lamorte G, Mazza T, Carella M, Gelati M, Valente EM, Simeone A,Vescovi
Cell Death & Disease – September 2018
Human Fetal Neural Stem Cells for Neurodegenerative Disease Treatment.
Ferrari D, Gelati M, Profico DC, Vescovi AL
Results And Problems In Cell Differentiation – 2018
2017
Fabrication of nanofibrous electrospun scaffolds from a heterogeneous library of co- and self-assembling peptides”
A cura di Mahboubeh Maleki, Antonino Natalello, Raffaele Pugliese, Fabrizio Gelain
Acta Biomaterialia – January 2017
Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques.
Napolitano F, Booth Warren E, Migliarini S, Punzo D, Errico F, Li Q, Thiolat ML, Vescovi AL, Calabresi P, Bezard E, Morelli M, Konradi C, Pasqualetti M, Usiello A.
PLOS ONE – July 2017
Extracellular vesicles are independent metabolic units with asparaginase activity
Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S.
Nature Chemical Biology – September 2017
2016
Stem cells therapy for ALS
Mazzini L, Vescovi A, Cantello R, Gelati M, Vercelli A.
Expert Opinion On Biological Therapy – January 2016
A biocompatibility study of new nanofibrous scaffolds for nervous system regeneration.
Raspa A., Marchini A., Pugliese R., Mauri M., Maleki M., Vasita R., Gelain F.
Nanoscale – January 2016
Recent therapeutic approaches for spinal cord injury
Raspa A, Pugliese R, Maleki M, Gelain F.
Biotechnology & Bioengineering – February 2016
Glial degeneration with oxidative damage drives neuronal demise in MPSII disease
Cristina Zalfa, Chiara Verpelli, Francesca D’Avanzo, Rosella Tomanin, Cinzia Vicidomini, Laura Cajola, Renzo Manara, Carlo Sala, Maurizio Scarpa, Angelo Luigi Vescovi, Lidia De Filippis
Cell Death & Disease – August 2016
Peptidic biomaterials: from self-assembling to regenerative medicine
Pugliese R. and Gelain F.
Trends in Biotechnology – October 2016
Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?
A cura di: Atassi N., Beghi E., Blanquer M., Boulis NM., Cantello R., Caponnetto C., Chiò A., Dunnett SB., Feldman EL., Vescovi A., Mazzini L. – Collaboratori: Bendotti C., Bersano E., Brajkovic S., Car P., De Marchi F., Fantozzi R., Follenzi A., Gelati M., Giorgi C., Grilli M., Guenzi P., La Bella V., Mancardi GL., Panzarasa G., Poloni M., Profico D., Silani V., Sorarù G., Spataro R., Stecco A., Vercelli A.
Cytotherapy – Ottobre 2016
2015
Human neural stem cell transplantation in ALS: initial results from a phase I trial.
Mazzini L, Gelati M, Profico DC, Sgaravizzi G, Projetti Pensi M, Muzi G, Ricciolini C, Rota Nodari L, Carletti S, Giorgi C, Spera C, Domenico F, Bersano E, Petruzzelli F, Cisari C, Maglione A, Sarnelli MF, Stecco A, Querin G, Masiero S, Cantello R, Ferrari D, Zalfa C, Binda E, Visioli A, Trombetta D, Novelli A, Torres B, Bernardini L, Carriero A, Prandi P, Servo S, Cerino A, Cima V, Gaiani A, Nasuelli N, Massara M, Glass J, Sorarù G, Boulis NM, Vescovi AL.
Journal Of Translational Medicine – January 2015
The Big Bluff of Amyotrophic Lateral Sclerosis Diagnosis: The Role of Neurodegenerative Disease Mimics.
Bicchi I, Emiliani C, Vescovi A, Martino S.
Neurodegenerative Diseases – 2015
2014
Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury.
Cigognini D, Silva D, Paloppi S, Gelain F
Journal of Biomedical Nanotechnology – February 2014
Modeling and analysis of early aggregation events of BMHP1-derived self-assembling peptides
Saracino G and Gelain F
Journal of Biomolecular Structure & Dynamics – 2014
Adult stem cell as new advanced therapy for experimental neuropathic pain treatment.
Franchi S, Castelli M, Amodeo G, Niada S, Ferrari D, Vescovi A, Brini AT, Panerai AE, Sacerdote P.
Biomed Research International – 2014
2013
Synthesis and Characterization of Designed BMHP1-Derived Self-Assembling Peptides for tissue engineering applications
Silva D, Natalello A, Sanii B, Vasita R, Saracino GAA, Zuckermann RN, Doglia SM, Gelain F
Nanoscale – January 2013
A Novel Bioactive Peptide: Assessing its Activity Over Murine Neural Stem Cells and its Potential for Neural Tissue Engineering
Caprini A, Silva D, Zanoni I, Cunha C, Volontè C, Vescovi A, Gelain F
New Biotechnology – June 2013
Murine neural stem cells model Hunter disease in vitro: glial cell-mediated neurodegeneration as a possible mechanism involved
Fusar Poli E, Zalfa C, D’Avanzo F, Tomanin R, Carlessi L, Bossi M, Nodari LR, Binda E, Marmiroli P, Scarpa M, Delia D, Vescovi AL, De Filippis L.
Cell Death & Disease – November 2013
Culturing and expansion of “clinical grade” precursors cells from the fetal human central nervous system.
Gelati M, Profico D, Projetti-Pensi M, Muzi G, Sgaravizzi G, Vescovi AL.
Methods In Molecular Biology – 2013
2012
Differential pathotropism of non-immortalized and immortalized human neural stem cell lines in a focal demyelination model.
Ferrari D, Zalfa C, Nodari LR, Gelati M, Carlessi L, Delia D, Vescovi AL, De Filippis L.
Cellular And Molecular Life Sciences – April 2012
Long-term survival of human neural stem cells in the ischemic rat brain upon transient immunosuppression.
Franchi S, Valsecchi AE, Borsani E, Procacci P, Ferrari D, Zalfa C, Sartori P, Rodella LF, Vescovi A, Maione S, Rossi F, Sacerdote P, Colleoni M, Panerai AE.
Pain – April 2012
New Bioactive Motifs and Their Use in Functionalized Self-Assembling Peptides for NSC Differentiation and Neural Tissue Engineering
Gelain F, Cigognini D, Caprini A, Silva D, Colleoni B, Donegá B, Antonini S, Cohen BE, Vescovi A.
Nanoscale – April 2012
Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration in experimental neuropathy.
Franchi S, Valsecchi AE, Borsani E, Procacci P, Ferrari D, Zalfa C, Sartori P, Rodella LF, Vescovi A, Maione S, Rossi F, Sacerdote P, Colleoni M, Panerai AE.
Pain – April 2012
Nanomaterials design and tests for neural tissue engineering
Saracino GAA, Cigognini D, Silva D, Caprini A, Gelain F
Chemical Society Reviews – September 2012
2011
Transplantation of nanostructured composite scaffolds neuro-prosthetics results in tissue reconstruction, axonal regeneration and neurological recovery in the chronically injured rat spinal cord
Gelain F, Panseri S, Antonini S, Cunha C, Donega M, Lowery J, Taraballi F, Cerri G, Montagna M, Baldissera F, Vescovi A.
ACS Nano – January 2011
BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications
Gelain F, Silva D, Caprini A, Villa O, Taraballi F, Natalello A, Nam KT, Doglia SM, Vescovi A.
ACS Nano – March 2011
Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-assembling Scaffold
Cigognini D, Satta A, Colleoni B, Silva D, Donega’ M, Antonini S, Gelain F
PLOS ONE – May 2011
2010
GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex.
Middeldorp J, Boer K, Sluijs JA, De Filippis L, Encha-Razavi F, Vescovi AL, Swaab DF, Aronica E, Hol EM.
Development. – January 2010
Mild hypoxia enhances proliferation and multipotency of human neural stem cells.
Santilli G, Lamorte G, Carlessi L, Ferrari D, Rota Nodari L, Binda E, Delia D, Vescovi AL, De Filippis L.
PLOS ONE – January 2010
Robust generation of oligodendrocyte progenitors from human neural stem cells and engraftment in experimental demyelination models in mice.
Neri M, Maderna C, Ferrari D, Cavazzin C, Vescovi AL, Gritti A.
PLOS ONE – April 2010
Isolation of neural stem cells from neural tissues using the neurosphere technique.
Ferrari D, Binda E, De Filippis L, Vescovi AL.
Current Protocols In Stem Cell Biology – November 2010
Long-term survival of human neural stem cells in the ischemic rat brain upon transient immunosuppression
Rota Nodari L, Ferrari D, Giani F, Bossi M, Rodriguez-Menendez V, Tredici G, Delia D, Vescovi AL, De Filippis L.
Current Protocols In Stem Cell Biology – November 2010
2009
The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions.
Regenberg A, Mathews DJ, Blass DM, Bok H, Coyle JT, Duggan P, Faden R, Finkel J, Gearhart JD, Hillis A, Hoke A, Johnson R, Johnston M, Kahn J, Kerr D, King P, Kurtzberg J, Liao SM, McDonald JW, McKhann G, Nelson KB, Rao M, Siegel AW, Smith K, Solter D, Song H, Sugarman J, Vescovi A, Young W, Greely HT, Traystman RJ.
Journal Of Cerebral Blood Flow & Metabolism – January 2009
Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates.
Pluchino S, Gritti A, Blezer E, Amadio S, Brambilla E, Borsellino G, Cossetti C, Del Carro U, Comi G, ‘t Hart B, Vescovi A, Martino G.
Annals Of Neurology – September 2009
2008
Efficient in vitro labeling of human neural precursor cells with superparamagnetic iron oxide particles: relevance for in vivo cell tracking
Neri M, Maderna C, Cavazzin C, Deidda-Vigoriti V, Politi LS, Scotti G, Marzola P, Sbarbati A, Vescovi AL, Gritti A.
Stem Cells Research – February 2008
Adult neural stem cells.
Galli R, Gritti A, Vescovi AL.
Methods In Molecular Biology – 2008
Clonal analyses and cryopreservation of neural stem cell cultures.
Gritti A, Galli R, Vescovi AL.
Methods In Molecular Biology – 2008
Multipotential neural precursors transplanted into the metachromatic leukodystrophy brain fail to generate oligodendrocytes but contribute to limit brain dysfunction.
Givogri MI, Bottai D, Zhu HL, Fasano S, Lamorte G, Brambilla R, Vescovi A, Wrabetz L, Bongarzone E.
Developmental Neuroscience – 2008
2007
Learning in human neural networks on microelectrode arrays
Pizzi R, Cino G, Gelain F, Rossetti D, Vescovi A.L.
Methods In Molecular Biology – March 2007
The stem cells as a potential treatment for neurodegeneration.
Daniela F, Vescovi AL, Bottai D.
Methods In Molecular Biology – 2007
A novel, immortal, and multipotent human neural stem cell line generating functional neurons and oligodendrocytes
De Filippis L, Lamorte G, Snyder EY, Malgaroli A, Vescovi AL.
Stem Cells – 2007
2006
Designer self-assembling peptide nanofiber scaffolds for adult mouse neural stem cell 3-dimensional cultures.
Gelain F, Bottai D, Vescovi A, Zhang S.
Journal Of Clinical Virology – December 2006
Differentiated human neural stem cells: a new ex vivo model to study HHV-6 infection of the central nervous system.
De Filippis L, Foglieni C, Silva S, Vescovi AL, Lusso P, Malnati MS. J Clin Virol.
Journal Of Clinical Virology – December 2006
2003
Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis.
Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A, Furlan R, Comi G, Vescovi AL, Martino G.
Nature. – April 2003
Neural stem cells: an overview.
Galli R, Gritti A, Bonfanti L, Vescovi AL.
Circulation Research – April 2003
2002
Adult neural stem cells: plasticity and developmental potential.
Gritti A, Vescovi AL, Galli R.
Journal Of Physiology-Paris – January/March 2002
Hematopoietic potential of neural stem cells
Vescovi AL, Rietze R, Magli MC, Bjornson C.
Nature Medicine – June 2002
Clonal analyses and cryopreservation of neural stem cell cultures.
Vescovi AL, Galli R, Gritti A.
Methods In Molecular Biology – 2002
2001
The neural stem cells and their transdifferentiation capacity.
Vescovi AL, Galli R, Gritti A.
Biomedicine & Pharmacotherapy – May 2001
2000
Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS.
Villa A, Snyder EY, Vescovi A, Martínez-Serrano A.
Experimental Neurology – January 2000
The possibilities/perplexities of stem cells.
Snyder EY, Vescovi AL.
Nature Biotechnology – August 2000
Excitable properties in astrocytes derived from human embryonic CNS stem cells
Gritti A, Rosati B, Lecchi M, Vescovi AL, Wanke E.
European Journal Of Neuroscience – October 2000
Regulation of neuronal differentiation in human CNS stem cell progeny by leukemia inhibitory factor.
Galli R, Pagano SF, Gritti A, Vescovi AL.
Developmental Neuroscience – 2000
1999
Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo.
Bjornson CR, Rietze RL, Reynolds BA, Magli MC, Vescovi AL.
Science. – January 1999
Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation.
Vescovi AL, Parati EA, Gritti A, Poulin P, Ferrario M, Wanke E, Frölichsthal-Schoeller P, Cova L, Arcellana-Panlilio M, Colombo A, Galli R.
Experimental Neurology – March 1999
Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain.
Gritti A, Frölichsthal-Schoeller P, Galli R, Parati EA, Cova L, Pagano SF, Bjornson CR, Vescovi AL.
Journal Of Neuroscience Research – May 1999
Establishment and properties of neural stem cell clones: plasticity in vitro and in vivo.
Vescovi AL, Snyder EY. Brain Pathol.
Journal Of Neuroscience Research – July 1999
Isolation and intracerebral grafting of nontransformed multipotential embryonic human CNS stem cells.
Vescovi AL, Gritti A, Galli R, Parati EA.
Journal Of Neurotrama – August 1999
Lineage restriction of neuroepithelial precursor cells from fetal human spinal cord.
Quinn SM, Walters WM, Vescovi AL, Whittemore SR.
Journal Of Neuroscience Research – September 1999
1996
Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.
Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, Wanke E, Faravelli L, Morassutti DJ, Roisen F, Nickel DD, Vescovi AL.
The Journal Of Neuroscience – February 1996
Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.
Gritti A, Parati EA, Cova L, Frolichsthal P, Galli R, Wanke E, Faravelli L, Morassutti DJ, Roisen F, Nickel DD, Vescovi AL.
The Journal Of Neuroscience – February 1996
Is there a neural stem cell in the mammalian forebrain?
Weiss S, Reynolds BA, Vescovi AL, Morshead C, Craig CG, van der Kooy D.
Trends In Neuroscience – September 1996
1995
Basic fibroblast growth factor supports the proliferation of epidermal growth factor-generated neuronal precursor cells of the adult mouse CNS.
Gritti A, Cova L, Parati EA, Galli R, Vescovi AL.
Neuroscience Letters – February 1995
1993
bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells.
Vescovi AL, Reynolds BA, Fraser DD, Weiss S.
Neuron – November 1993